The following research articles have been fully or partially funded by the ADRF.

High-resolution profilometric assessment of early enamel erosion

A Diep, S Ranjitkar, C Hall†, A Brook, JA Kaidonis, GC Townsend

Acid wear is a growing concern because of recent increases in children and young-adults. This study describes a new nano-technique to investigate small effects of 10 to 20 seconds of acid attack simulating a sports drink on tooth enamel. The technique was able to detect immediate roughening and loss of surface enamel and highlights the need for early detection and management.

MicroCT image analysis of Apert teeth

S Ranjitkar, C Petroff, R Yong, G Townsend, P Anderson

Apert syndrome can be a debilitating growth condition related to premature fusion of skull bones in children. This study used high-resolution 3D imaging technique (termed microCT) on baby teeth of affected individuals and found alterations in tooth size (i.e. larger or smaller size) and shape (i.e. twisted appearance). Our results may be useful in orthodontic management of affected individuals.


Altered tooth size associated with premature fusion of skull bones

M. Mian, S. Ranjitkar, G.C. Townsend, and P.J. Anderson

Gene therapy holds promise for treatment of many growth conditions, including craniosynostosis (i.e. premature fusion of skull bones). This study investigated the effects of two glypican genes, GPC1 and GPC3, on tooth size in genetically-modified mice. Mice with missing GPC3 gene had larger teeth, than mice with missing GPC1 gene. This trend is consistent with recent reports on lower jaw size in those mice, implying that the glypicans have similar effects on tooth development and jaw formation.


Influence of access cavity designs, root canal enlargement and short-term calcium hydroxide intracanal medicament on fracture susceptibility of root-filled teeth

R. Haddadin, P.V. Abbott, T. Sercombe, N. Boyd

Fracture of teeth after root canal treatment is a common problem often leading to extraction. This project tested the susceptibility of teeth to fracture following root canal treatment and restoration. Simulated chewing, extent of access cavity preparations, degree of root canal enlargement and short-term use of calcium hydroxide had no effect on the force required to fracture lower molars that were otherwise intact apart from the access cavity. Overall, root canal treatment per se did not affect fracture susceptibility of teeth with intact marginal ridges.